Life Sciences and Clinical Investigation Dual Degree

Degree Types: MS/PhD

The Driskill Graduate Program in the Life Sciences (DGP) and the Master of Science in Clinical Investigation (MSCI) is dual degree program leading to the PhD and MS degrees. The DGP/MSCI degree, leverages CTSA and NUCATS Institute resources to extend integrated clinical/translational research training to DGP PhD students. This dual degree is designed to connect PhD trainees in life sciences early in their research experience with clinician investigators who can help them see the value of understanding the clinical needs of patients. These DGP/MSCI trainees will have a more informed perspective on the intersection between translational and clinical research. They are positioned to become bi-directional collaborators and innovators in this critical space.

Graduates of this program will be uniquely positioned to work in multidisciplinary teams in academic, corporate or government positions to accelerate the translation of research discoveries that improve human health.

Additional resources:

Life Sciences and Clinical Investigation Dual Degree Courses

IGP 401-0 Biochemistry I (1 Unit)  

Structures and properties of proteins, nucleic acids, and polymers, complex and simple carbohydrates, and lipids; thermodynamic principles applied to biologic systems; molecules; structural correlates and functional expressions.

IGP 403-0 Advanced Immunology (1 Unit)  

Topics in immunology. Discussion of current experimental papers.

IGP 405-0 Cell Biology (1 Unit)  

Structure and function of cells and their organelles. Morphological, molecular, and physiological approaches to solving cell-biological problems.

IGP 410-0 Molecular Biology (1 Unit)  

Topics in molecular biology and the mechanisms of gene and cellular regulation.

Prerequisites: Past or simultaneous enrollment in IGP 401-0 or equivalent.

IGP 420-0 Introduction to Pharmacology (1 Unit)  

This lecture-based course begins with an introduction to the basic principles of pharmacology, namely pharmacodynamics (what the drug does to the body) and pharmacokinetics (what the body does to the drug). The subsequent topics apply these basic pharmacological principles to a discussion of the normal physiology, the pathophysiological processes that produce disease, and the targeted pharmacological treatment of disease. This integrated physiological, pharmacological and clinical approach will be applied to the following global topics in sequence: Neuropharmacology (Peripheral and Central Nervous Systems), Antimicrobial and Anticancer Chemotherapy, Cardiovascular and Renal Physiology and Pharmacology, Endocrine and Immunopharmacology.

IGP 422-0 Introduction to Translational Research (1 Unit)  

This course is intended to introduce basic life sciences and clinical research graduate students to the thought processes involved in human disease research and its translation into therapy by providing an overview of disease processes, how they are treated, how basic biological science is used to develop those treatments, and the role of various stakeholders in the translational research pipeline. At the end of this course the student should understand the medical rationale for studying basic pathomechanisms and how to utilize that rationale to design studies and grant proposals. In addition, the student will obtain background knowledge for further, disease- or organ-specific upper-level courses.

IGP 425-0 Topics in Drug Discovery (1 Unit)  

Key precedents and contemporary topics in drug discovery research in academia and industry. Principles of drug design and action, pharmacogenetics, macromolecular target identification and characterization, bioassays and animal models of disease, study design and information management.

IGP 430-0 Genetics (1 Unit)  

Genetics of prokaryotic and eukaryotic organisms; gene regulation and variation; chromosome structure and behavior; linkage and recombination; quantitative and population genetics; biochemical and developmental genetics; and manipulation of genes in organisms, including humans.

IGP 433-0 Advanced Microbial Pathogenesis (1 Unit)  

Properties of microorganisms important in the pathogenesis genesis of infectious diseases. Emphasis on molecular aspects of virulence as they relate to host-parasite interactions.

IGP 435-0 Signal transduction and human diseases (1 Unit)  

Integrated discussion of different superfamilies of signaling receptors and their effectors. Pathways discussed include G-protein linked, growth factors and cytokines, nuclear receptors and transcription factors.

IGP 436-1 Drugs and the Brain (1 Unit)  

Graduate neuropharmacology course with a mix of didactic instruction (33%) and in-depth classroom discussion of primary research papers (66%). The course is not a survey course, but rather will cover selected topics in neuropharmacology with the goals of 1) informing the student of the latest neuropharmacology knowledge, 2) inculcating a rigorous approach to examination of the scientific literature, and 3) encouraging best practices in experimental design.

IGP 440-0 Immunology (1 Unit)  

An integrated view of contemporary immunology: antigens, antibodies, humoral and cell-mediated immune responses, cellular interactions, and regulation of immune responses.

IGP 442-0 Microbiology (1 Unit)  

Structure and function, taxonomy and replication of infectious agents. Host-parasite interactions and microbial diseases.

Prerequisites: IGP 405-0, IGP 410-0, and IGP 401-0 or equivalent.

IGP 450-0 Tumor Cell Biology (1 Unit)  

Basic aspects of the neoplastic phenotype, including morphologic, biochemical, genetic, cytogenetic, and other features; regulation of cell proliferation and differentiation; basic concepts in molecular mechanisms of chemical, viral, and radiation carcinogenesis; solid tumor growth, progression, and metastasis; tumor immunology.

IGP 456-0 Topics in Developmental Biology (1 Unit)  

Survey of current models in mammalian and nonmammalian development. Empahsis on stem cell biology. Discussion of experimental papers.

IGP 466-0 Structural Basis of Signal Transduction (1 Unit)  

The structural and thermodynamic basis by which protein- protein or protein-nucleic acid interactions mediate signal transduction. Signaling pathways used to explore how the structural biological mechanisms underlying these pathways can be experimentally determined and understood.

IGP 475-0 Virology (1 Unit)  

Mechanisms of genome replication, control of gene expression, and protein functions are analyzed in RNA and DNA viruses.

IGP 480-0 Molecular Mechanisms of Carcinogenesis (1 Unit)  

Current literature relating experimental approaches and recent discoveries in the fields of cell biology, virology, and molecular genetics to mechanisms of carcinogenesis. Advanced level.

IGP 484-0 Quantitative Biology: Statistics and Data Analysis for Life Scientists (1 Unit)  

Parametric statistics (such as the familiar t test); nonparametric and simulation approaches (such as permutation tests) better suited to "real" data; and a conceptual survey of more sophisticated data-mining/machine-learning techniques.

IGP 485-0 Data Science For Biomedical Researchers (1 Unit)  

Introduction to the data and analysis tools from several areas of study within the Biomedical Informatics research spectrum. Didactic instruction as an introduction to the topics followed by hands-on demonstrations and exercises to reveal practical use of relevant software tools.

IGP 486-0 Advance Bioinformatics and Genome Informatics (1 Unit)  

The course will be oriented towards graduate students in HSIP, DGP and related programs. It will consist of lectures/seminars, each two hours in duration. The course will introduce various high-throughput technologies, such as microarray and Next Generation Sequence data, for measuring and analyzing gene expression, chromosomal deletions and amplifications, methylation patterns and genome architecture. Further, various algorithms and bioinformatics tools for analyzing the produced high-dimensional data will be discussed. The course begins with couple of introductory lectures in the biology part (Experimental/Technology part - 2 hours duration - no laboratory) followed by presentations on algorithms and data analysis (Bioinformatics part - 2 hours duration). Finally some recently published articles using these technologies will be discussed. At the end of the course, the students will be expected to gain an overview of the current highthroughput technologies and use of associated bioinformatics algorithms and analytical methods. Students will gain experience in genomic data visualization tools to analyze multi -omics data for gene expression, genome rearrangement, somatic mutations and copy number variation. The course will conclude with analyzing and conducting pathway analysis on the resultant cancer gene lists and integration of clinical data.

IGP 493-0 Molecular Basis of Natural History (0 Unit)  

The molecular basis of natural history course will examine important examples from Nature and use the approaches of biochemistry, molecular biology and genetics to categorize and analyze the natural products produced by bacteria, plants and animals and examine how they have impacted human history. Most 2 hour sessions will be devoted to a particular topic. After an introduction by faculty, course participants will examine the subject further through the discussion of assigned papers from the literature or other texts. Some sessions will also be devoted solely to presentations of topics by the students. All students will submit and essay on a topic covered by the course or a related topic in natural history.

IGP 494-0 Colloqium on Integrity in Biomedical Research (0 Unit)  

Required by National Institutes of Health (NIH) but does not count as one of the required IGP courses.

IGP 495-0 Science and Society (0 Unit)  

Exploration of the foundations of modern science and discussion of how these ideas impact social issues in the biomedical sciences (creationism, abortion, euthanasia, eugenics, cryogenics, replacement therapies, animal rights).

IGP 496-1 Introduction to Life Science Research (0 Unit)  

Provides first-year IGP students with tools to develop the knowledge base and skill set necessary for competent research.

IGP 496-2 Introduction to Life Science Research (0 Unit)  

Provides first-year IGP students with tools to develop the knowledge base and skill set necessary for competent research.

IGP 496-3 Introduction to Life Science Research (1 Unit)  

Provides first-year IGP students with tools to develop the knowledge base and skill set necessary for competent research.

IGP 499-0 Independent Study (1-3 Units)  

SEE DEPT FOR SECTION AND PERMISSION NUMBERS.

IGP 590-0 Research (1-3 Units)  

Independent investigation of selected problems pertaining to thesis or dissertation.

MSCI 311-0 Clinical Research Design, Methods, and Grant Writing (1 Unit)  

This course presents students with a comprehensive survey of concepts vital to a career in clinical & translational science. The course will fill a void in the curriculum by functioning as foundation from which other MSCI courses will spring and afford students an opportunity to interface with basic clinical and translational concepts before delving into these subjects more granularly as they pursue the degree. Items that will be reviewed in more depth later such as reviewing study designs and recognizing the types of research problems that lend themselves to interventional study designs are approached here as a way of better preparing students for the challenges ahead.

MSCI 321-1 Biostatistics for Clinical Investigators 1 (1 Unit)  

This is an introductory yet rigorous course that covers classic statistical inference and methods. Applications and interpretation of data are emphasized. Mathematical proofs and derivations are not covered; however, theory is addressed conceptually. Readings are intended to be theoretical. Lectures, homework and exams will focus on applying statistical procedures using SPSS and interpreting data. Due to time restrictions, only selected topics are covered. The use of SPSS is a course requirement.

MSCI 322-0 Introduction to Epidemiology for Clinical Investigators (1 Unit)  

This course is an introduction to the field of epidemiology and its application. Epidemiology is the study of the distribution of disease and determinants of disease in human populations. The most commonly used study designs in epidemiology are observational rather than experimental. The course will introduce these study designs and basic analytic methods. Emphasis will be on the appropriate interpretation of epidemiologic evidence, including the attribution of causality when describing an exposure-disease relationship.

MSCI 330-0 Electronic Health Record Data as a Foundation for Clinical Research (1 Unit)  

This course will introduce electronic health records as a data source, considerations for working with protected health information and integration of health record data with other data sources and will explore clinical and research applications of medical records and discuss methods and tools for data validation and analysis.

MSCI 335-0 Clinical Trials (1 Unit)  

The goal of this course is to provide students with the skills to design, conduct, analyze, interpret, and report the rest of a clinical trial. Trials by definition are experimental and are used to determine whether a clinical intervention works.

MSCI 421-0 Biostatistics for Clinical Investigators 2 (1 Unit)  

This course covers advanced modeling techniques for statistical inference. Applications and interpretation of data are emphasized. Mathematical proofs and derivations are not covered; however, theory is addressed conceptually. Lectures, homework and exams will focus on applying statistical procedures using SPSS and interpreting data. Due to time restrictions, only selected topics are covered. The use of SPSS is a course requirement.

MSCI 422-0 Introduction to Translational Research (1 Unit)  

This course is intended to introduce the basic life sciences graduate student to the thought processes involved in human disease research by providing an overview of disease processes, how they are treated, and how basic biological science is used to develop those treatments.

MSCI 445-0 Writing & Peer Reviewing for Publication for Clinical Investigators (1 Unit)  

This course represents a HANDS-ON experience that will review and discuss the steps involved in preparing, peer reviewing, and revising manuscripts for publication. Students are expected to prepare and hand in written work for each class and to attend and participate actively in class discussion. Advance reading and writing are essential for this course.

MSCI 490-0 Independent Study (1 Unit)  

Permission of instructor and department required.

MSCI 499-0 Research Project (2 Units)  

The MSCI Research Project serves as a capstone for the degree; students enroll at or near the end of their coursework and signifies the culmination of a project that they have been working on throughout their time in the program. This is not a traditional classroom course but follows an independent study approach. Research must be data-driven and of publishable quality: clinical case studies or IRB submissions are not acceptable.